A Protein Identified to Make Mesothelioma More Susceptible Towards Treatment

In most types of cancer treatments, doctors heavily rely on chemotherapy as their traditional line of treatment.


cell death in mesothelioma
                mesothelioma.net

Mesothelioma happens to be a rare form of cancer which is caused due to the exposure of asbestos related products for over a long period of time.

As malignant mesothelioma has proved resistant to the above protocol, patients have to face a grim prognosis.

As per an article published on the mesothelioma.net, the final respite in the mesothelioma treatment has come from a California based drug company, focusing on a specific protein to make mesothelioma more susceptible to chemotherapy.

The company has recently announced success in the first three phases of its clinical trials.



Also Read: 5 Known Reasons Why You Require A Mesothelioma Attorney


 

How Therapeutic Protein Blocks Nutrient to Mesothelioma Cells

The name of the company is Polaris Group which has long been exploring a therapeutic protein called pegargiminase.

It works by blocking the supply of arginine to malignant mesothelioma cells.

As you might be aware of Arginine is mainly required for the survival of cells which is often needed in higher amounts in cancer cells.

The researchers continue to explore if their therapy can be able to create such a condition where malignant cells could lead to stress along with altered gene expression and cell death without affecting the normal and healthy functioning of cells.

John Bomalaski, who's the EVP of the company says, “Preclinical data revealed various biochemical mechanisms that provide compelling rationales for combining pegargiminase with other agents, and we are exploring these potential synergies in our global clinical trial program.” he said.

 

Survival Rates Tend to Increase In Malignant Mesothelioma Cases

The Polaris Group while exploring their strategy to affect malignant cells has announced that phase 3 clinical trial for mesothelioma treatment (ADI-PEG 20) has been successful.

After conducting the above research, the company is looking forward to apply to the U.S. Food and Drug Administration (FDA) for marketing approval next year.

Please note that the successful mesothelioma trials were specifically carried out in some countries including the United States. Due to their successful research, the company is planning to pursue its marketing goal early in 2023.

 

Also Read: Immunotherapy: Best Treatment Option In the Dynamic Immuno-Oncology (IO) Market 

 

 

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