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Association Found Between Immune-Mediated Diseases and Increased Cancer Risk

As per a cohort study, diseases that are known as immune mediated ones are associated with a higher risk of developing cancer. The study conducted in this regard also stressed that organ specific immune mediated diseases happen to be more strongly related to local cancers as compared to extra local cancers.


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The above result or finding shows that immune mediated diseases are prone to be converted into cancer. A stronger association was also observed while studying the organ specific immune related diseases. 

In cases of organ specific immune related diseases, the chances are that a person becomes the victim of both local cancers and extra local cancers as well. The above research was conducted in cohort study published in JAMA Oncology.

The study was actually conducted in as many as 61,500 patients. Out of them 26,834 cancer cases among 61,496 patients were observed. This is what the investigation observed, “Many immune-mediated diseases were associated with increased risk of cancers in the involved organs and in the near and distant organs or different systems,” it revealed.

The finding investigated in this regard concluded that organ specific immune mediated diseases had an overall risk of developing both local and total cancer. Some cases with asthma were also found in the study conducted.

A total of 48 immune related diseases were studied and spotted for further study. Researches conducted further studies with or without the presence of these disease. 

The data for immune- mediated disease were at increased risk of lung cancer (multivariable-adjusted HR, 1.36; 95% CI, 1.20-1.53), lymphoma (multivariable-adjusted HR, 1.49; 95% CI, 1.26-1.75), and liver cancer (HR, 1.75; 95% CI, 1.30-2.36).

The research revealed up to 13 immune related diseases associated with a higher risk of cancer for diseases like sicca syndrome of the small intestine (HR, 8.49; 95% CI, 1.18-61.32) and mouth cancers (13.59; 95% CI, 1.86-99.09), as well as Guillain- Barré syndrome in those with soft tissue cancer (HR, 11.17; 95% CI, 1.56-79.80).

“These findings support the importance of local and systemic immunoregulation in carcinogenesis and may inform future research elucidating the role of immunoregulation and microbiota in cancer development,” the investigation concluded.


Also Read: Sublingual Immunotherapy Effectiveness In Treating Lung Cancer




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